Research Work published by the US FETUS ORG
Current Research protocols
Open Spina Bifida/ Mylomeningocele
Previous publications:
Quintero R, Chmait RH. Monochorionic diamniotic twin pregnancy with selective fetal growth restriction Type II: sonographic and fetoscopic findings of poor prognosis.Ultrasound Obstet Gynecol. 2018 Feb;51(2):280. doi: 10.1002/uog.18995. PMID: 29417679
Chmait RH, Chon AH, Korst LM, Llanes A, Kontopoulos EV, Quintero RA.
Risks of Preterm Premature Rupture of Membranes and Preterm Birth Post Fetoscopy Based on Location of Trocar Insertion Site. Am J Perinatol. 2018 Jul;35(8):801-808. doi: 10.1055/s-0037-1620268. Epub 2018 Jan 10. PMID:29320800
Lapa Pedreira DA, Acacio GL, Gonçalves RT, Sá RAM, Brandt RA, Chmait RH, Kontopoulos EV, Quintero RA. Percutaneous fetoscopic closure of large open spina bifida using a bilaminar skin substitute. Ultrasound Obstet Gynecol. 2018 Oct;52(4):458-466. doi: 10.1002/uog.19001.
PMID:29314321
Chon AH, Korst LM, Grubbs BH, Kontopoulos EV, Quintero RA, Chmait RH.
Risk factors for fetomaternal bleeding after laser therapy for twin-twin transfusion syndrome. Prenat Diagn. 2017 Dec;37(12):1232-1237. doi: 10.1002/pd.5173. Epub 2017 Dec 3.
PMID: 29071724
Chmait RH, Kontopoulos EV, Chon AH, Korst LM, Llanes A, Quintero RA
Amniopatch treatment of iatrogenic preterm premature rupture of membranes (iPPROM) after fetoscopic laser surgery for twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2017 Jun;30(11):1349-1354.doi:10.1080/14767058.2016.1214123. Epub 2016 Aug 10.
PMID:27686840
Pedreira DA, Reece EA, Chmait RH, Kontopoulos EV, Quintero RA Fetoscopic repair of spina bifida: safer and better? Ultrasound Obstet Gynecol. 2016 Aug;48(2):141-7. doi: 10.1002/uog.15987. No abstract available.
PMID:27273812
Quintero RA, Kontopoulos E, Chmait RH.
Laser Treatment of Twin-to-Twin Transfusion Syndrome. Twin Res Hum Genet. 2016 Jun;19(3):197-206. doi: 10.1017/thg.2016.28.
PMID:27203606
Kontopoulos E, Chmait RH, Quintero RA Twin-to-Twin Transfusion Syndrome: Definition, Staging, and Ultrasound Assessment. Twin Res Hum Genet. 2016 Jun;19(3):175-83. doi: 10.1017/thg.2016.34. Review.
PMID:27203605
Van Winden KR, Quintero RA, Kontopoulos EV, Korst LM, Llanes A, Chmait RH. Decreased Total Placental Mass Found in Twin-Twin Transfusion Syndrome Gestations with Selective Growth Restriction. Fetal Diagn Ther. 2016;40(2):116-22. doi: 10.1159/000442153. Epub 2016 Jan 20.
PMID: 26784929
Pedreira DA, Zanon N, Nishikuni K, Moreira de Sá RA, Acacio GL, Chmait RH, Kontopoulos EV, Quintero RA. Endoscopic surgery for the antenatal treatment of myelomeningocele: the CECAM trial.. Am J Obstet Gynecol. 2016 Jan;214(1):111.e1-111.e11. doi: 10.1016/j.ajog.2015.09.065. Epub 2015 Sep 18.
PMID:26386383
Chmait RH, Chon AH, Schrager SM, Kontopoulos EV, Quintero RA, Vanderbilt DL.
Donor catch-up growth after laser surgery for twin-twin transfusion syndrome.
Early Hum Dev. 2015 Dec;91(12):751-4. doi: 10.1016/j.earlhumdev.2015.08.006. Epub 2015 Sep 10.
PMID: 26364515
Moon-Grady AJ, Morris SA, Belfort M, Chmait R, Dangel J, Devlieger R, Emery S, Frommelt M, Galindo A, Gelehrter S, Gembruch U, Grinenco S, Habli M, Herberg U, Jaeggi E, Kilby M, Kontopoulos E, Marantz P, Miller O, Otaño L, Pedra C, Pedra S, Pruetz J, Quintero R, Ryan G, Sharland G, Simpson J, Vlastos E, Tworetzky W, Wilkins-Haug L, Oepkes D International Fetal Cardiac Intervention Registry: A Worldwide Collaborative Description and Preliminary Outcomes. International Fetal Cardiac Intervention Registry. J Am Coll Cardiol. 2015 Jul 28;66(4):388-99. doi: 10.1016/j.jacc.2015.05.037.
PMID: 26205597
Chmait RH, Kontopoulos EV, Jackson M, Horenstein J, Timor-Tritsch I, Quintero RA
Selective Reduction Using Intravascular Potassium Chloride Injection after Laser Surgery for Twin-Twin Transfusion Syndrome. Fetal Diagn Ther. 2016;39(4):306-10. doi: 10.1159/000431255. Epub 2015 Jun 9.
PMID:26067899
Patel S, Quintero RA, Kontopoulos EV, Korst LM, Llanes A, Chmait RH.
Abnormal umbilical artery Doppler findings in the recipient twin before laser surgery for twin-twin transfusion syndrome. J Ultrasound Med. 2015 May;34(5):843-6. doi: 10.7863/ultra.34.5.843.
PMID:25911718
Kontopoulos E, Quintero R, Barrett J, Chmait R.
Which twin is which? A proposed solution for the labeling of twins at birth.Am J Obstet Gynecol. 2015 Aug;213(2):245-6. doi: 10.1016/j.ajog.2015.03.050. Epub 2015 Mar 26.
PMID: 25816785
Van Winden KR, Quintero RA, Kontopoulos EV, Korst LM, Llanes A, Chmait RH.
Pre-Operative Twin Anemia/Polycythemia in the Setting of Twin-Twin Transfusion Syndrome (TTTS).Fetal Diagn Ther. 2015;37(4):274-80. doi: 10.1159/000365919. Epub 2015 Feb 14.
PMID: 25721425
Peeters SH, Akkermans J, Westra M, Lopriore E, Middeldorp JM, Klumper FJ, Lewi L, Devlieger R, Deprest J, Kontopoulos EV, Quintero R, Chmait RH, Smoleniec JS, Otaño L, Oepkes D. Identification of essential steps in laser procedure for twin-twin transfusion syndrome using the Delphi methodology: SILICONE study. Ultrasound Obstet Gynecol. 2015 Apr;45(4):439-46. doi: 10.1002/uog.14761. Epub 2015 Mar 5.PMID:25504904
Van Winden KR, Quintero RA, Kontopoulos EV, Korst LM, Llanes A, Chmait RH.
Perinatal survival in cases of twin-twin transfusion syndrome complicated by selective intrauterine growth restriction. J Matern Fetal Neonatal Med. 2015 Sep;28(13):1549-53.doi:10.3109/14767058.2014.960834. Epub 2014 Sep 29.
PMID:25184748
Chmait RH, Kontopoulos E, Quintero R; USFetus Consortium Dual twin survival after laser surgery for twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2014 Aug;44(2):244. doi: 10.1002/uog.13425. No abstract available. PMID: 25088513
Chmait RH, Kontopoulos EV, Quintero RA. Sequential laser surgery for twin-twin transfusion syndrome. Am J Perinatol. 2014 Sep;31 Suppl 1:S13-8. doi: 10.1055/s-0034-1382774. Epub 2014 Jun 17. Review.
PMID:24936936
Pedreira DA, Zanon N, de Sá RA, Acacio GL, Ogeda E, Belem TM, Chmait RH, Kontopoulos E, Quintero RA.Fetoscopic single-layer repair of open spina bifida using a cellulose patch: preliminary clinical experience.J Matern Fetal Neonatal Med. 2014 Nov;27(16):1613-9. doi: 10.3109/14767058.2013.871701. Epub 2014 Jan 13.PMID: 24299030
USFetus Consortium, Quintero RA, Chmait R, Kontopoulos E. Laser treatment of twin-twin transfusion syndrome: what do the data really show? Am J Obstet Gynecol. 2013 Aug;209(2):157-8. doi: 10.1016/j.ajog.2013.03.018. Epub 2013 Mar 21. No abstract available.
PMID: 23524169
Quintero RA, Kontopoulos EV, Quintero LF, Landy DC, Gonzalez R, Chmait RH.The observed vs. expected lung-to-head ratio does not correct for the effect of gestational age on the lung-to-head ratio. J Matern Fetal Neonatal Med. 2013 Apr;26(6):552-7. doi: 10.3109/14767058.2012.736000. Epub 2012 Nov 9.
PMID: 23046345
Schrey S, Huber A, Hecher K, Quintero R, Alkazaleh F, Moise KJ Jr, Allbert JR, Schneider C, Palermo M, Yinon Y, Chmait RH, Windrim R, Ryan G.Vascular limb occlusion in twin-twin transfusion syndrome (TTTS): case series and literature review. Am J Obstet Gynecol. 2012 Aug;207(2):131.e1-10. doi: 10.1016/j.ajog.2012.06.005. Epub 2012 Jun 11. Review.
PMID:22840724
Sosa-Sosa C, Bermúdez C, Chmait RH, Kontopoulos E, Córdoba Y, Guevara-Zuloaga F, Steffensen T, Quintero RA Intraluminal tracheal occlusion using a modified 8-mm Z-stent in a sheep model of left-sided congenital diaphragmatic hernia. J Matern Fetal Neonatal Med. 2012 Nov;25(11):2346-53. doi: 10.3109/14767058.2012.695825. Epub 2012 Jun 19.
PMID:22631591
Quintero RA, Quintero LF, Chmait R, Gómez Castro L, Korst LM, Fridman M, Kontopoulos EV. The quantitative lung index (QLI): a gestational age-independent sonographic predictor of fetal lung growth. Am J Obstet Gynecol. 2011 Dec;205(6):544.e1-8. doi: 10.1016/j.ajog.2011.07.031. Epub 2011 Jul 22.
PMID:21944224
Chmait RH, Kontopoulos EV, Korst LM, Llanes A, Petisco I, Quintero RA. Stage-based outcomes of 682 consecutive cases of twin-twin transfusion syndrome treated with laser surgery: the USFetus experience. Am J Obstet Gynecol. 2011 May;204(5):393.e1-6. doi: 10.1016/j.ajog.2011.02.001. Epub 2011 Mar 15.
PMID:21411051
WAPM Consensus Group on Twin-to-Twin Transfusion, Baschat A, Chmait RH, Deprest J, Gratacós E, Hecher K, Kontopoulos E, Quintero R, Skupski DW, Valsky DV, Ville Y.Twin-to-twin transfusion syndrome (TTTS).J Perinat Med. 2011 Mar;39(2):107-12. doi: 10.1515/JPM.2010.147. Epub 2010 Dec 13.
PMID: 21142846
Pathak B, Quintero R, Kontopoulos E, Assaf S, Miller D, Chmait RH. Postoperative middle cerebral artery peak systolic velocity changes confirm physiological principles of the sequential laser technique for twin-twin transfusion syndrome. Fetal Diagn Ther. 2010;28(3):140-4. doi: 10.1159/000319803. Epub 2010 Sep 14.
PMID: 20838031
Chmait R, Kontopoulos E, Quintero R.Fetoscopic management of complicated monochorionic twins.Clin Obstet Gynecol. 2009 Dec;52(4):647-53. doi: 10.1097/GRF.0b013e3181beda76. Review.
PMID:20393415
Quintero R, Kontopoulos EV, Barness E, Steffensen TS, Hilbelink D, Chmait R, Benirschke K, Bornick PW. Twin-twin transfusion syndrome in a dichorionic-monozygotic twin pregnancy: The end of a paradigm?
Fetal Pediatr Pathol. 2010 Jan;29(2):81-8. doi: 10.3109/15513811003615013. No abstract available.
PMID:20334482
Quintero RA, Gomez Castro LA, Bermudez C, Chmait RH, Kontopoulos EV.In utero management of fetal lower urinary tract obstruction with a novel shunt: a landmark development in fetal therapy. J Matern Fetal Neonatal Med. 2010 Aug;23(8):806-12. doi: 10.3109/14767050903443491.
PMID:19968590
Quintero RA, Chmait RH, Bornick PW, Kontopoulos EV.Trocar-assisted selective laser photocoagulation of communicating vessels: a technique for the laser treatment of patients with twin-twin transfusion syndrome with inaccessible anterior placentas. J Matern Fetal Neonatal Med. 2010 Apr;23(4):330-4. doi: 10.3109/14767050903177177.
PMID:19941443
Chmait RH, Kontopoulos E, Bornick PW, Maitino T, Quintero RA Triplets with feto-fetal transfusion syndrome treated with laser ablation: the USFetus experience. J Matern Fetal Neonatal Med. 2010 May;23(5):361-5. doi: 10.1080/14767050903177201.
PMID:19658042
Chmait RH, Chavira E, Kontopoulos EV, Quintero RA. Third trimester fetoscopic laser ablation of type II vasa previa. J Matern Fetal Neonatal Med. 2010 May;23(5):459-62. doi: 10.1080/14767050903156718.
PMID:19637106
Chmait RH, Aghajanian P, Kontopoulos EV, Quintero RA.Prenatal diagnosis of spontaneous septostomy of the dividing membranes in complicated monochorionic diamniotic multiple gestations. J Ultrasound Med. 2009 May;28(5):663-8.
PMID:19389906
Quintero RA, Chmait R The con trial. Am J Obstet Gynecol. 2009 Mar;200(3):e14-5; author reply e15. doi: 10.1016/j.ajog.2008.07.041. Epub 2008 Nov 6. No abstract available.
PMID:18992859
Quintero RA, Chmait RH, Carver J, Bornick PW, Allen MH, Kontopoulos EV
.In utero fetal oximetry via visible light spectroscopy in twin-twin transfusion syndrome.
Am J Obstet Gynecol. 2008 Dec;199(6):639.e1-4. doi: 10.1016/j.ajog.2008.05.026. Epub 2008 Jul 29.
PMID:18667174
Chmait RH, Quintero RA Operative fetoscopy in complicated monochorionic twins: current status and future direction. Curr Opin Obstet Gynecol. 2008 Apr;20(2):169-74. doi: 10.1097/GCO.0b013e3282f52f72. Review.
PMID: 18388818
Chmait RH, Korst LM, Bornick PW, Allen MH, Quintero RA Fetal growth after laser therapy for twin-twin transfusion syndrome. Am J Obstet Gynecol. 2008 Jul;199(1):47.e1-6. doi: 10.1016/j.ajog.2007.11.062. Epub 2008 Mar 4.
PMID: 18295741
Quintero RA, Ishii K, Chmait RH, Bornick PW, Allen MH, Kontopoulos EV. Sequential selective laser photocoagulation of communicating vessels in twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2007 Oct;20(10):763-8.
PMID:17763279
Kontopoulos EV, Quintero RA, Chmait RH, Bornick PW, Russell Z, Allen MH.Percent absent end-diastolic velocity in the umbilical artery waveform as a predictor of intrauterine fetal demise of the donor twin after selective laser photocoagulation of communicating vessels in twin-twin transfusion syndrome.Ultrasound Obstet Gynecol. 2007 Jul;30(1):35-9.
PMID:17587216
Chmait RH, Rossi AC, Quintero RA Paradoxical scalloped placenta with polyhydramnios in twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2007 Jan;20(1):29-32.
PMID:17437196
Chang YL, Chmait RH, Bornick PW, Allen MH, Quintero RA.
Am J Obstet Gynecol. 2006 Aug;195(2):478-83. Epub 2006 May 16.
PMID:16707082
Quintero RA, Chmait RH, Murakoshi T, Pankrac Z, Swiatkowska M, Bornick PW, Allen MH.Surgical management of twin reversed arterial perfusion sequence.Am J Obstet Gynecol. 2006 Apr;194(4):982-91.PMID:16580287
Quintero RA, Kontopoulos EV, Chmait R, Bornick PW, Allen M. Management of twin-twin transfusion syndrome in pregnancies with iatrogenic detachment of membranes following therapeutic amniocentesis and the role of interim amniopatch. Ultrasound Obstet Gynecol. 2005 Nov;26(6):628-33.
PMID:16217744
Quintero RA, Huhta J, Suh E, Chmait R, Romero R, Angel J.In utero cardiac fetal surgery: laser atrial septotomy in the treatment of hypoplastic left heart syndrome with intact atrial septum.Am J Obstet Gynecol. 2005 Oct;193(4):1424-8.
PMID: 16202736
Ishii K, Chmait RH, Martínez JM, Nakata M, Quintero RA.Ultrasound assessment of venous blood flow before and after laser therapy: approach to understanding the pathophysiology of twin-twin transfusion syndrome.Ultrasound Obstet Gynecol. 2004 Aug;24(2):164-8.
PMID: 15287054
Nakata M, Martínez JM, Díaz C, Chmait R, Quintero RA.Intra-amniotic Doppler measurement of blood flow in placental vascular anastomoses in twin-twin transfusion syndrome.Ultrasound Obstet Gynecol. 2004 Jul;24(1):102-3. No abstract available.
PMID: 15229926
Nakata M, Chmait RH, Quintero RA.Umbilical cord occlusion of the donor versus recipient fetus in twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2004 May;23(5):446-50.
PMID: 15133793
Quintero RA, Chmait RH.The cocoon sign: a potential sonographic pitfall in the diagnosis of twin – twin transfusion syndrome. Ultrasound Obstet Gynecol. 2004 Jan;23(1):38-41.
PMID: 14970997